– Substitute use of penicillin in patients with hypersensitivity to this drug during infectious treatment.
– Treatment of upper respiratory tract infections e.g. sinusitis, pharyngitis, otitis media. Lower respiratory tract infections e.g. pneumonia, acute and chronic bronchitis. Skin and soft tissue infections of mild to moderate severity.
– Treatment of unicellular infections and toxoplasmosis.
– Supportive therapy for gastro-duodenal ulcer and inflammation caused by Helicobacter pylori. Prevention and treatment of Mycobacterium avium infections in patients with immuno deficiency,
– Prophylaxis of occasional infections.
Warnings and cautions when taking drugs
Do not store above 25°C.
Dosage and Administration
– Usual doses in patients 12 years of age or older: 250 mg twice daily, increased to 500 mg twice daily if necessary in severe infection for 7 to 14 days. Children may be given 7.5 mg/kg bodyweight each time, twice daily for 5 to 10 days.
– For treatment and prophylaxis of disseminated infection due to Mycobacterium avium complex: 500 mg twice daily; for treatment, it should be given with other antimycobacterials.
– For the eradication of H. pylori associated with peptic ulcer disease: 500 mg twice daily, clarithromycin is given with another antibacterial and either a proton pump inhibitor or a histamine H2-receptor antagonist, for 7 to 14 days.
– In patients with severe renal impairment (creatinine clearance of less than 30 ml/minutes): Dosage should be halved