• Administration:

This medication may be administered by intravenous injection, by intravenous infusion, or by intramuscular injection, the preferred method for initial emergency use being intravenous injection.

• Dosage:

* Severe asthma: The dose is 100 mg to 500 mg, depending on the severity of the condition. This dose may be repeated at intervals of 2, 4 or 6 hours as indicated by the patient’s response and clinical condition.

* For children: the dose may be reduced, it is governed more by the severity of the condition and response of the patient than by age or body weight but should not be less than 25 mg daily.

* Shock due to infection: The high initial dose is 1g by IV. When the severe shock occurs, the initial dose is 50mg/kg and may be repeated at intervals of 4 and/or 24 hours. High dose corticosteroid therapy should be continued between 48 – 72 hours. If the therapy continued beyond 48 – 72 hours, the hypernatremia may occur.

* Anaphylactic reactions: Initial must be IV adrenalin and then IV hydrocortisone 100-300mg.

* Acute adrenal impairment: The initial dose is 100mg and repeated at intervals of every 8 hours. This dose is usually reduced in 5 days to the maintenance 20 – 30 mg/ 24 hours.

* Intra-articular injection: 5 – 50 mg, depend on the joints’ size.