– Fludarabine phosphate injection is given 25 mg/m² administered intravenously over a period of approximately 30 minutes daily for five consecutive days. Each 5 days course of treatment should commence every 28 days. Each course of treatment is about 6 cycles.– Dissolve lyophilized components in 2 ml of water and should be used within 8 hours of reconstitution.– Fludarabine phosphate is diluted un 100 ml or 125 ml Dextrose 5% or NaCl 0,9% to intravenous infusion. Or diluted in 10 ml NaCl 0,9% to slow intravenous injection.– The dosage of Fludarabine phosphate is based on the clinical response and the tolerance of drug.– The patients with moderate impairment of renal function (Creatinine clearance: 30-70 ml/min) should have a half dose reduction.Fludarabine phosphate injection should not be administered to patients with severely impaired renal function ( Creatinine clearance less than 30 ml/min).