In this situation, the Ministry of Health and the Ministry of Science and Technology have supported a number of research projects on cancer drugs, such as: Research on anastrozol synthesis for breast cancer treatment of the Institute of Medicine; Research on tamoxifen citrate synthesis of active ingredients, used for dosage breast cancer drug Novaldex of Institute of Biochemistry; Research extraction technology of biologically active substances from the red tree leaves and Vietnamese periwinkle for production of  anticancer drugs and export of MA. Vuong Chi Hung; Research on screening a number of pharmaceutical to isolate new substances that kill cancer cells of vice Prof. PhD Hoang ThanhHuong; Research on synthesis of Hydroxyurea treatment for cancer by vice Prof. PhD. Nguyen QuangDat; However, for many different reasons, no specific product has been produced based on these results. Therefore,  cancer treatment service still depends on import.In this situation, the Ministry of Health and the Ministry of Science and Technology have supported a number of research projects on cancer drugs, such as: Research on anastrozol synthesis for breast cancer treatment of the Institute of Medicine; Research on tamoxifen citrate synthesis of active ingredients, used for dosage breast cancer drug Novaldex of Institute of Biochemistry; Research extraction technology of biologically active substances from the red tree leaves and Vietnamese periwinkle for production of anticancer drugs and export of MA. Vuong Chi Hung; Research on screening a number of pharmaceutical to isolate new substances that kill cancer cells of vice Prof. PhD Hoang ThanhHuong; Research on synthesis of Hydroxyurea treatment for cancer by vice Prof. PhD. Nguyen QuangDat; However, for many different reasons, no specific product has been produced based on these results. Therefore,  cancer treatment service still depends on import.

 

Since 2008, BinhDinh Phamarceutical – Medical Equipment Company has established a group specializing in doing research and developing drugs and cancer treatment aimed at researching  and manufacturing generic injectable freeze – drying injections – that is used to treat cancer. We have gained very encouraging results as having completed 01 research and 01 state project for testing production and have been granted 13 registrations of drugs by the Ministry of Health.Since 2008, BinhDinh Phamarceutical – Medical Equipment Company has established a group specializing in doing research and developing drugs and cancer treatment aimed at researching  and manufacturing generic injectable freeze – drying injections – that is used to treat cancer. We have gained very encouraging results as having completed 01 research and 01 state project for testing production and have been granted 13 registrations of drugs by the Ministry of Health.

 

To achieve these results, the research team has bravely integrated and applied many technology solutions to accomplish its objectives:To achieve these results, the research team has bravely integrated and applied many technology solutions to accomplish its objectives:

 

Isolator technology:

 

Isolator technology is derived from the nuclear industry and has been used in the pharmaceutical industry since the 1980s and is now widely used in the manufacture of sterile drugs, some toxicity drugs, such as: cancer treatment, highly active drugs such as hormone …Isolator technology is derived from the nuclear industry and has been used in the pharmaceutical industry since the 1980s and is now widely used in the manufacture of sterile drugs, some toxicity drugs, such as: cancer treatment, highly active drugs such as hormone …

 

The technology of isolator production helps separate manufacturing sector with humans. The use of isolator technology is to minimize human interventions in processing areas, which can lead to reduce not only the risk of microbial contamination from the environment to sterile products but also the impact of toxic chemicals on people and production environments.The technology of isolator production helps separate manufacturing sector with humans. The use of isolator technology is to minimize human interventions in processing areas, which can lead to reduce not only the risk of microbial contamination from the environment to sterile products but also the impact of toxic chemicals on people and production environments.

 

Lyophilized Technology:

 

Lyophilizing is a process of aqueous solution which was frozen at lower temperatures than the otecti temperature of the solution. The solvent type was directly eliminated from the solid phase without going through the liquid phase under reduced pressure (usually less than 100 mmHg), then the dried product is obtained. Currently, lyophilized techniques are widely applied in manufacturing injections, eye drops and a number of other formats, such as drug delivery system used in lyophilized ophthalmology, rapid disintegration tablets, microcapsules … as these techniques have several advantagesLyophilizing is a process of aqueous solution which was frozen at lower temperatures than the otecti temperature of the solution. The solvent type was directly eliminated from the solid phase without going through the liquid phase under reduced pressure (usually less than 100 mmHg), then the dried product is obtained. Currently, lyophilized techniques are widely applied in manufacturing injections, eye drops and a number of other formats, such as drug delivery system used in lyophilized ophthalmology, rapid disintegration tablets, microcapsules … as these techniques have several advantages

 

+ Drying process is carried out at low temperature to limit the speed of chemical reactions at very low levels

 

+ Drying process is carried out at low temperature to limit the speed of chemical reactions at very low levels

 

+ Dry product obtained with high specific surface area can be dissolved quickly in need of being dissolved back.

 

+ Dry product obtained with high specific surface area can be dissolved quickly in need of being dissolved back.

 

+ Drugs are classified into dose vials before freeze-drying in aqueous solution to easily achieve the homogeneous requirements of drug content in each unit of product. So the contamination is minimized compared to other drugs jarred to vial in powder form

 

+ Drugs are classified into dose vials before freeze-drying in aqueous solution to easily achieve the homogeneous requirements of drug content in each unit of product. So the contamination is minimized compared to other drugs jarred to vial in powder form

 

+ It reduces the oxidation of drugs by limiting the presence of oxygen in the production process because the product is dried in a vacuum environment and jarred in a vacuum or under pressure of inert gas put in when the lid is replaced.

 

+ It reduces the oxidation of drugs by limiting the presence of oxygen in the production process because the product is dried in a vacuum environment and jarred in a vacuum or under pressure of inert gas put in when the lid is replaced.

 

The technology of aseptic production:

 

Drugs are injected directly into the patient’s body in the form of intramuscular or intravenous injection. And not only are the effects of drugs required but also the sterility and absolute safety when injections for patients must be ensured. Therefore, from design, construction of buildings, machinery and equipment investment, HVAC systems, and materials, production processes, the producers must adhere to strict rules to ensure no bacteria in the production process. The process of manufacturing sterile products must be carried out in clean areas where people, equipment and raw materials must go through airlocks. Clean areas should be maintained at an appropriate standard of cleanliness, and the air supply is filtered through a membrane filter with appropriate filter performance.Drugs are injected directly into the patient’s body in the form of intramuscular or intravenous injection. And not only are the effects of drugs required but also the sterility and absolute safety when injections for patients must be ensured. Therefore, from design, construction of buildings, machinery and equipment investment, HVAC systems, and materials, production processes, the producers must adhere to strict rules to ensure no bacteria in the production process. The process of manufacturing sterile products must be carried out in clean areas where people, equipment and raw materials must go through airlocks. Clean areas should be maintained at an appropriate standard of cleanliness, and the air supply is filtered through a membrane filter with appropriate filter performance.

 

So far, based on the research results achieved, BinhDinhPhamarceutical – Medical Equipment Company decided to expand the scale of production and continue to invest in research and development of cancer treatments. On 15.07.2013 the Ministry of Science and Technology approved the project ‘Research and development of technology applications to produce a number of cancer drugs in BinhDinhPhamarceutical  – Medical Equipment Company and the project will begin in 2014. The project consists of 5 themes and 01 testing production project with the goal: to build and install drug production lines – lyophilized injection and lines for the production of tablets for cancer treatment with PIC / S-GMP standard, research new 12 products, complete the technology process for 6 products to improve production categories up to 25-30 drugs for cancer treatment served cure and prevention. In addition, the project will include study to produce isolator equipment dedicated to the medical establishments for drug injection.So far, based on the research results achieved, BinhDinhPhamarceutical – Medical Equipment Company decided to expand the scale of production and continue to invest in research and development of cancer treatments. On 15.07.2013 the Ministry of Science and Technology approved the project ‘Research and development of technology applications to produce a number of cancer drugs in BinhDinhPhamarceutical  – Medical Equipment Company and the project will begin in 2014. The project consists of 5 themes and 01 testing production project with the goal: to build and install drug production lines – lyophilized injection and lines for the production of tablets for cancer treatment with PIC / S-GMP standard, research new 12 products, complete the technology process for 6 products to improve production categories up to 25-30 drugs for cancer treatment served cure and prevention. In addition, the project will include study to produce isolator equipment dedicated to the medical establishments for drug injection.

DRUGS OF CANCER TREATMENT PRODUCED BY BIDIPHAR: